Fighting tubulin-targeting anticancer drug toxicity and resistance
نویسندگان
چکیده
منابع مشابه
Laser Optofluidics in Fighting Multiple Drug Resistance
The book combines fields which experience increasing interest in recent years: optofluidics, microfluidics and fighting multiple drug resistance (MDR) seen as part of infectious diseases domain. Ther eported results are of interest for life sciences, environment quality control and biomedical basic and applied research. Biomedical specialists, chemists, physicists, public health experts and eve...
متن کاملFighting resistance.
A pioneer in the early identification of drug resistance in tuberculosis patients, Sir John Crofton and his colleagues' seminal research into multidrug therapy for tuberculosis patients in the 1950s laid the groundwork for the WHO-recommended tuberculosis treatment today. This is one of the last interviews he gave before he passed away on 3 November at the age of 97, after a career that spanned...
متن کاملDrug targeting of leptin resistance.
Leptin regulates glucose, lipid and energy homeostasis as well as feeding behavior, serving as a bridge between peripheral metabolically active tissues and the central nervous system (CNS). Indeed, this adipocyte-derived hormone, whose circulating levels mirror fat mass, not only exerts its anti-obesity effects mainly modulating the activity of specific hypothalamic neurons expressing the long ...
متن کاملMultidrug resistance protein 2 implicates anticancer drug-resistance to sorafenib.
Sorafenib and sunitinib is a small molecule inhibitor of certain receptor tyrosine kinases, and have improved outcomes for patients with advanced renal cell carcinoma. Inhibitory concentration of 50% cell growth of sorafenib significantly rose to 6.4-fold in a multidrug resistance protein 2 (MRP2) transfected cell line versus control cell line. The concentration of sorafenib was significantly d...
متن کاملSynthesis of (Z)-(arylamino)-pyrazolyl/isoxazolyl-2-propenones as tubulin targeting anticancer agents and apoptotic inducers.
A new class of pyrazole and isoxazole conjugates were synthesized and evaluated for their cytotoxic activity against various human cancer cell lines. These compounds have shown significant cytotoxicity with lower IC50 values. FACS results revealed that A549 cells treated with these compounds arrested cells at the G2/M phase of the cell cycle apart from activating cyclin B1 protein levels. Parti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrine-Related Cancer
سال: 2017
ISSN: 1351-0088,1479-6821
DOI: 10.1530/erc-17-0120